A dopamine D2L receptor antagonist
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JNJ-37822681 (hydrochloride)

Item No. 37428

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-[(3,4-difluorophenyl)methyl]-4-piperidinyl]-6-(trifluoromethyl)-3-pyridazinamine, dihydrochloride
CAS Number
2108806-02-4
Molecular Formula
C17H17F5N4 • 2HCl
Formula Weight
445.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
FC1=CC=C(CN2CCC(CC2)NC3=CC=C(C(F)(F)F)N=N3)C=C1F.Cl.Cl
InChi Code
InChI=1S/C17H17F5N4.2ClH/c18-13-2-1-11(9-14(13)19)10-26-7-5-12(6-8-26)23-16-4-3-15(24-25-16)17(20,21)22;;/h1-4,9,12H,5-8,10H2,(H,23,25);2*1H
InChi Key
UOLHGUUKFNZTNS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $218

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    10 mg

    $387

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    25 mg

    $845

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    Product Description

    JNJ-37822681 is a dopamine D2L receptor antagonist (Ki = 0.158 µM).1 It is selective for dopamine D2L receptors over dopamine D1 and D3, α1-adrenergic, and histamine H1 receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A and 5-HT2C in radioligand binding assays (Kis = >3, 1.159, >5, 4.931, 2.896, and >4 µM, respectively). JNJ-37822681 inhibits apomorphine-induced stereotypy and D-amphetamine-induced hyperlocomotion in rat models of psychosis (ED50s = 0.19 and 1 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Langlois, X., Megens, A., Lavreysen, H., et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J. Pharmacol. Exp. Ther. 342(1), 91-105 (2012).