A synthetic peptide fragment of PR 39 peptide
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PR 26 (trifluoroacetate salt)

Item No. 37460

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Proline-arginine-rich 26
Molecular Formula
C153H242N50O28 • XCF3COOH
Formula Weight
3229.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
RRRPRPPYLPRPRPPPFFPPRLPPRI-OH
Solubility(Learn about Variance in Solubility)
Water: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@H](C(N5CCC[C@H]5C(N[C@@H](CCCNC(N)=N)C(N6CCC[C@H]6C(N[C@@H](CCCNC(N)=N)C(N7CCC[C@H]7C(N8CCC[C@H]8C(N9CCC[C@H]9C(N[C@H](C(N[C@H](C(N%10CCC[C@H]%10C(N%11CCC[C@H]%11C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N%12CCC[C@H]%12C(N%13CCC[C@H]%13C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)CC%14=CC=CC=C%14)=O)CC%15=CC=CC=C%15)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C153H242N50O28.C2HF3O2/c1-7-89(6)119(145(230)231)191-123(208)97(41-17-65-174-149(161)162)181-127(212)111-50-26-74-196(111)141(226)115-54-31-79-201(115)138(223)105(83-88(4)5)188-122(207)96(40-16-64-173-148(159)160)180-126(211)110-49-25-73-195(110)142(227)116-55-32-80-202(116)139(224)106(86-91-36-12-9-13-37-91)190-125(210)102(84-90-34-10-8-11-35-90)186-131(216)113-52-28-76-198(113)143(228)118-57-33-81-203(118)144(229)117-56-30-78-200(117)136(221)101(45-21-69-178-153(169)170)185-129(214)108-47-23-71-193(108)134(219)99(43-19-67-176-151(165)166)183-130(215)109-48-24-72-194(109)137(222)104(82-87(2)3)189-124(209)103(85-92-58-60-93(204)61-59-92)187-132(217)112-51-27-75-197(112)140(225)114-53-29-77-199(114)135(220)100(44-20-68-177-152(167)168)184-128(213)107-46-22-70-192(107)133(218)98(42-18-66-175-150(163)164)182-121(206)95(39-15-63-172-147(157)158)179-120(205)94(154)38-14-62-171-146(155)156;3-2(4,5)1(6)7/h8-13,34-37,58-61,87-89,94-119,204H,7,14-33,38-57,62-86,154H2,1-6H3,(H,179,205)(H,180,211)(H,181,212)(H,182,206)(H,183,215)(H,184,213)(H,185,214)(H,186,216)(H,187,217)(H,188,207)(H,189,209)(H,190,210)(H,191,208)(H,230,231)(H4,155,156,171)(H4,157,158,172)(H4,159,160,173)(H4,161,162,174)(H4,163,164,175)(H4,165,166,176)(H4,167,168,177)(H4,169,170,178);(H,6,7)/t89-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-;/m0./s1
InChi Key
BSHFLUTZNDHVFL-XXUORWJISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Proline-arginine-rich 26 (PR 26) is a synthetic peptide fragment of the antibiotic peptide PR 39 peptide (Item No. 36717).1 It is active against E. coli, S. typhimurium, S. choleraesuis, and S. suis (MICs = 2, 1, 2, and 1 µg/ml, respectively). PR 26 (3 µM) inhibits S. typhimurium infection of rat IEC-6 intestinal cells. It increases phagocytosis of S. choleraesuis in isolated porcine neutrophils when used at a concentration of 2 µM. PR 26 (1 µM) induces chemotaxis in isolated porcine neutrophils.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shi, J., Ross, C.R., Chengappa, M.M., et al. Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide. Antimicrob Agents Chemother. 40(1), 115-121 (1996).

    2. Huang, H.J., Ross, C.R., and Blecha, F. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. J. Leukoc. Biol. 61(5), 624-629 (1997).