An antiviral peptide
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P9R (trifluoroacetate salt)

Item No. 37463

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-asparaginylglycyl-L-alanyl-L-isoleucyl-L-cysteinyl-L-tryptophylglycyl-L-prolyl-L-cysteinyl-L-prolyl-L-threonyl-L-alanyl-L-phenylalanyl-L-arginyl-L-glutaminyl-L-isoleucylglycyl-L-asparaginyl-L-cysteinylglycyl-L-arginyl-L-phenylalanyl-L-arginyl-L-valyl-L-arginyl-L-cysteinyl-L-cysteinyl-L-arginyl-L-isoleucyl-L-arginine, trifluoroacetate
Molecular Formula
C144H232N52O35S5 • XCF3COOH
Formula Weight
3412.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
NGAICWGPCPTAFRQIGNCGRFRVRCCRIR-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.O=C(NCC(N[C@H](C(N[C@@](C(N[C@@H](CS[H])C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCC(N3CCC[C@H]3C(N[C@@H](CS[H])C(N4CCC[C@H]4C(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@](C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CS[H])C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CS[H])C(N[C@@H](CS[H])C(N[C@@H](CCCNC(N)=N)C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)CC6=CC=CC=C6)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)C)=O)[C@H](CC(N)=O)N[H]
InChi Code
InChI=1S/C144H232N52O35S5.C2HF3O2/c1-12-71(6)109(192-123(215)88(45-46-101(146)198)179-119(211)84(38-24-48-162-140(151)152)176-124(216)90(55-77-31-17-15-18-32-77)182-113(205)75(10)173-136(228)112(76(11)197)194-131(223)100-44-30-54-196(100)137(229)98(69-236)189-130(222)99-43-29-53-195(99)107(204)64-171-116(208)92(57-79-60-167-82-36-22-21-35-80(79)82)184-128(220)97(68-235)188-135(227)110(72(7)13-2)191-114(206)74(9)172-104(201)61-168-115(207)81(145)58-102(147)199)132(224)170-63-106(203)175-93(59-103(148)200)126(218)185-94(65-232)117(209)169-62-105(202)174-83(37-23-47-161-139(149)150)118(210)183-91(56-78-33-19-16-20-34-78)125(217)177-86(40-26-50-164-142(155)156)121(213)190-108(70(4)5)133(225)180-85(39-25-49-163-141(153)154)120(212)186-96(67-234)129(221)187-95(66-233)127(219)178-87(41-27-51-165-143(157)158)122(214)193-111(73(8)14-3)134(226)181-89(138(230)231)42-28-52-166-144(159)160;3-2(4,5)1(6)7/h15-22,31-36,60,70-76,81,83-100,108-112,167,197,232-236H,12-14,23-30,37-59,61-69,145H2,1-11H3,(H2,146,198)(H2,147,199)(H2,148,200)(H,168,207)(H,169,209)(H,170,224)(H,171,208)(H,172,201)(H,173,228)(H,174,202)(H,175,203)(H,176,216)(H,177,217)(H,178,219)(H,179,211)(H,180,225)(H,181,226)(H,182,205)(H,183,210)(H,184,220)(H,185,218)(H,186,212)(H,187,221)(H,188,227)(H,189,222)(H,190,213)(H,191,206)(H,192,215)(H,193,214)(H,194,223)(H,230,231)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166);(H,6,7)/t71-,72-,73-,74-,75-,76+,81-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,108-,109-,110-,111-,112-;/m0./s1
InChi Key
XKJROCKISJSYAJ-GKABRGBASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

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    Product Description

    P9R is a peptide with antiviral activity.1 It inhibits viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, influenza A subtypes H1N1 and H7N9, and rhinovirus in plaque reduction assays (IC50s = 0.9, 2.2, 4.2, 0.6, 0.9, and 5.7 µg/ml, respectively). In vivo, P9R (50 µg/animal three times over two days) increases survival and reduces H1N1 particle-forming units (PFUs) in the lungs to a similar extent as the influenza neuraminidase inhibitor zanamivir (Item No. 15123) in H1N1-infected mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, H., To, K.K.W., Sze, K.-H., et al. A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2. Nat. Commun. 11(1), 4252 (2020).