A cell-permeable peptide and TRPA1 inhibitor
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T100-Mut (trifluoroacetate salt)

Item No. 37464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C161H271N49O42S • XCF3COOH
Formula Weight
3597.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Myr-WKVRQRNKKVQQQESQTALVVNQRCLFA-OH (where Myr = myristoyl)
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
OC(C(F)(F)F)=O.OC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](NC(CCCCCCCCCCCCC)=O)CC1=CNC2=C1C=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)=O)CS)=O)=O)CC3=CC=CC=C3)=O)C)=O
InChi Code
InChI=1S/C161H271N49O42S.C2HF3O2/c1-17-18-19-20-21-22-23-24-25-26-30-52-124(221)185-111(76-92-79-182-94-45-32-31-44-93(92)94)147(240)190-97(48-35-38-69-164)143(236)206-126(84(6)7)153(246)197-100(51-41-72-181-161(177)178)133(226)191-101(53-60-116(165)213)136(229)187-98(49-39-70-179-159(173)174)134(227)202-112(77-122(171)219)148(241)189-95(46-33-36-67-162)132(225)186-96(47-34-37-68-163)142(235)207-127(85(8)9)154(247)198-105(57-64-120(169)217)140(233)193-102(54-61-117(166)214)138(231)192-103(55-62-118(167)215)139(232)194-107(59-66-125(222)223)141(234)204-114(80-211)151(244)196-106(58-65-121(170)218)144(237)210-130(90(16)212)157(250)183-88(14)131(224)199-109(74-83(4)5)150(243)208-129(87(12)13)156(249)209-128(86(10)11)155(248)203-113(78-123(172)220)149(242)195-104(56-63-119(168)216)137(230)188-99(50-40-71-180-160(175)176)135(228)205-115(81-253)152(245)200-108(73-82(2)3)146(239)201-110(75-91-42-28-27-29-43-91)145(238)184-89(15)158(251)252;3-2(4,5)1(6)7/h27-29,31-32,42-45,79,82-90,95-115,126-130,182,211-212,253H,17-26,30,33-41,46-78,80-81,162-164H2,1-16H3,(H2,165,213)(H2,166,214)(H2,167,215)(H2,168,216)(H2,169,217)(H2,170,218)(H2,171,219)(H2,172,220)(H,183,250)(H,184,238)(H,185,221)(H,186,225)(H,187,229)(H,188,230)(H,189,241)(H,190,240)(H,191,226)(H,192,231)(H,193,233)(H,194,232)(H,195,242)(H,196,244)(H,197,246)(H,198,247)(H,199,224)(H,200,245)(H,201,239)(H,202,227)(H,203,248)(H,204,234)(H,205,228)(H,206,236)(H,207,235)(H,208,243)(H,209,249)(H,210,237)(H,222,223)(H,251,252)(H4,173,174,179)(H4,175,176,180)(H4,177,178,181);(H,6,7)/t88-,89-,90+,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,126-,127-,128-,129-,130-;/m0./s1
InChi Key
WVAAAUUKLWMQDW-ZUTAKRCISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $183

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    10 mg

    $347

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    Product Description

    T100-Mut is a cell-permeable peptide and transient receptor potential ankyrin 1 (TRPA1) inhibitor that contains the C-terminal sequence of Tmem100-3Q, a mutant form of the endogenous peptide Tmem100.1 It reduces calcium flux induced by mustard oil, a TRPA1 agonist, in primary mouse dorsal root ganglia (DRG) when used at a concentration of 200 nM. Subcutaneous administration of T100-Mut (5 µl of a 2 mM solution) into the hind paw reduces paw licking induced by mustard oil but not the TRP vanilloid 1 (TRPV1) agonist capsaicin (Item Nos. 92350 | 10010743) in mice. It also reduces mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) or paclitaxel (Item No. 10461) in wild-type, but not TRPV1 knockout, mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weng, H.J., Patel, K.N., Jeske, N.A., et al. Tmem100 is a regulator of TRPA1-TRPV1 complex and contributes to persistent pain. Neuron 85(4), 833-846 (2015).