A peptide substrate for various serine/threonine protein kinases
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Ziptide (trifluoroacetate salt)

Item No. 37466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-lysyl-L-leucyl-L-asparaginyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-prolyl-glycine, trifluoroacetate salt
Molecular Formula
C65H109N19O19 • XCF3COOH
Formula Weight
1460.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KKLNRTLSFAEPG-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(C(F)(F)F)=O.NCCCC[C@H](N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C65H109N19O19.C2HF3O2/c1-34(2)28-43(78-55(94)40(19-11-13-25-67)75-54(93)39(68)18-10-12-24-66)58(97)80-46(31-49(69)87)60(99)76-41(20-14-26-72-65(70)71)56(95)83-52(37(6)86)63(102)81-44(29-35(3)4)59(98)82-47(33-85)61(100)79-45(30-38-16-8-7-9-17-38)57(96)74-36(5)53(92)77-42(22-23-50(88)89)64(103)84-27-15-21-48(84)62(101)73-32-51(90)91;3-2(4,5)1(6)7/h7-9,16-17,34-37,39-48,52,85-86H,10-15,18-33,66-68H2,1-6H3,(H2,69,87)(H,73,101)(H,74,96)(H,75,93)(H,76,99)(H,77,92)(H,78,94)(H,79,100)(H,80,97)(H,81,102)(H,82,98)(H,83,95)(H,88,89)(H,90,91)(H4,70,71,72);(H,6,7)/t36-,37+,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,52-;/m0./s1
InChi Key
IWCLMIGILYRNID-GRWSJLCKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ziptide is a peptide substrate for various serine/threonine protein kinases, including MAPK activated protein kinase 2 (MAPKAPK2), MAPKAPK3, MAPKAPK5, checkpoint kinase 1 (Chk1), AMP-activated protein kinase (AMPK), and calcium/calmodulin-dependent protein kinase II (CamKII).1 It has been used to evaluate CamKII activity for inhibitor development.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, H., Armstrong, C.G., and Cohen, P. A non-radioactive method for the assay of many serine/threonine-specific protein kinases. Biochem J. 366(Pt 3), 977-981 (2002).

    2. Komiya, M., Asano, S., Koike, N., et al. Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor. Biooorg. Med. Chem. 20(23), 6840-6847 (2012).