A peptide antagonist of the IL-6 receptor
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S7 (trifluoroacetate salt)

Item No. 37467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-leucyl-L-seryl-L-leucyl-L-threonyl-L-arginyl-L-leucine, trifluoroacetate salt
Synonyms
  • Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH
Molecular Formula
C37H70N10O10 • XCF3COOH
Formula Weight
815.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
LSLITRL-OH
Solubility(Learn about Variance in Solubility)
1% HCOOH/H2O: Soluble
SMILES
OC(C(F)(F)F)=O.CC(C)C[C@H](N)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C37H70N10O10.C2HF3O2/c1-10-21(8)28(46-32(52)25(15-19(4)5)43-33(53)27(17-48)45-30(50)23(38)14-18(2)3)34(54)47-29(22(9)49)35(55)42-24(12-11-13-41-37(39)40)31(51)44-26(36(56)57)16-20(6)7;3-2(4,5)1(6)7/h18-29,48-49H,10-17,38H2,1-9H3,(H,42,55)(H,43,53)(H,44,51)(H,45,50)(H,46,52)(H,47,54)(H,56,57)(H4,39,40,41);(H,6,7)/t21-,22+,23-,24-,25-,26-,27-,28-,29-;/m0./s1
InChi Key
CGCUPVSMVDCCQB-GGLMJRKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $492

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    Cayman Chemical
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    Product Description

    S7 is a peptide antagonist of the IL-6 receptor.1,2 It inhibits IL-6 binding to the IL-6 receptor in a concentration-dependent manner.1 S7 (50 µM) inhibits IL-6-induced increases in VEGF levels in C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It reduces tumor volume in an IL-6-overexpressing C-33 A cervical cancer mouse xenograft model when administered at a dose of 50 mg/kg every two days. When coupled to cysteine and the surface of lipid nanoparticles (LNPs) encapsulating doxorubicin, S7 increases LNP glioma targeting and increases survival in a U251 glioblastoma mouse xenograft model. 2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Su, J.-L., Lai, K.-P., Chen, C.-A., et al. A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11), 4827-4835 (2005).

    2. Shi, W., Cui, X., Shi, J., et al. Overcoming the blood–brain barrier for glioma-targeted therapy based on an interleukin-6 receptor-mediated micelle system. RSC Adv. 7, 27162-27169 (2017).