A GABAA receptor allosteric agonist
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Ocinaplon

Item No. 37478

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]-methanone
CAS Number
96604-21-6
Synonyms
  • CL 273,547
Molecular Formula
C17H11N5O
Formula Weight
301.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
O=C(C1=C(N=CC=C2C3=CC=NC=C3)N2N=C1)C4=CC=CC=N4
InChi Code
InChI=1S/C17H11N5O/c23-16(14-3-1-2-7-19-14)13-11-21-22-15(6-10-20-17(13)22)12-4-8-18-9-5-12/h1-11H
InChi Key
OQJFBUOFGHPMSR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $96

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    10 mg

    $183

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    25 mg

    $431

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    50 mg

    $764

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    Product Description

    Ocinaplon is a GABAA receptor allosteric agonist.1 It potentiates GABA-induced currents in X. laevis oocytes expressing α1β2γ2, α2β2γ2, α3β2γ2, and α5β2γ2 subunit-containing recombinant GABAA receptors (EC50s = 3.07, 3.39, 4.59, and 3.79 µM, respectively). Ocinaplon increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats with a minimum effective dose (MED) of 3.1 mg/kg. It decreases clonic convulsions induced by pentylenetetrazole (Item No. 18682) in rats (ED50 = 7.5 mg/kg). Ocinaplon increases punished responding in a squirrel monkey conflict test (MED = 4 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lippa, A., Czobor, P., Stark, J., et al. Selective anxiolysis produced by ocinaplon, a GABAA receptor modulator. Proc. Natl. Acad. Sci. USA 102(20), 7380-7385 (2005).