An activator of p300
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CTB

Item No. 37480

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-benzamide
CAS Number
451491-47-7
Molecular Formula
C16H13ClF3NO2
Formula Weight
343.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
O=C(C1=C(OCC)C=CC=C1)NC2=CC=C(C(C(F)(F)F)=C2)Cl
InChi Code
InChI=1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)
InChi Key
YDXZSNHARVUYNM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $90

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    10 mg

    $142

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    25 mg

    $245

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    50 mg

    $444

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    Cayman Chemical
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    Product Description

    CTB is an activator of the histone acetyltransferase p300.1 It induces acetylation of core histones in HeLa cells when used at a concentration of 200 µM. CTB (85.43 µM) increases p53 acetylation and induces apoptosis in MCF-7 cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mantelingu, K., Kishore, A.H., Balasubramanyam, K., et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: Probed by surface-enhanced Raman spectroscopy. J. Phys. Chem. B 111(17), 4527-4534 (2007).

    2. Dastjerdi, M.N., Salahshoor, M.R., Mardani, M., et al. The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines. Adv. Biomed. Res. 2, 24 (2013).