An ApoA1 peptidomimetic
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RG33 (trifluoroacetate salt)

Item No. 37516

Safety Data Sheet (SDS) (PDF)
Technical Information
Molecular Formula
C175H282N42O51 • XCF3COOH
Formula Weight
3790.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
Ac-PALEDLRQGLLPVLESFKVSFLSALEEYTKKLN-NH2
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H]1CCCN1C([C@H](CC(C)C)NC([C@H](CC(C)C)NC(CNC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H]2CCCN2C(C)=O)=O)C)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)C)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C175H282N42O51.C2HF3O2/c1-87(2)70-115(188-134(226)83-185-146(240)109(54-59-132(179)224)192-148(242)108(47-37-67-184-175(182)183)191-158(252)118(73-90(7)8)203-164(258)125(82-139(235)236)207-152(246)112(57-62-137(231)232)195-157(251)117(72-89(5)6)200-145(239)98(22)187-169(263)130-48-38-68-216(130)100(24)222)155(249)209-126(77-94(15)16)174(268)217-69-39-49-131(217)170(264)214-141(96(19)20)171(265)208-121(76-93(13)14)159(253)196-113(58-63-138(233)234)153(247)210-128(85-219)167(261)205-122(78-101-40-27-25-28-41-101)162(256)190-107(46-33-36-66-178)154(248)213-140(95(17)18)172(266)212-129(86-220)168(262)206-123(79-102-42-29-26-30-43-102)163(257)202-120(75-92(11)12)161(255)211-127(84-218)166(260)186-97(21)144(238)199-116(71-88(3)4)156(250)194-110(55-60-135(227)228)150(244)193-111(56-61-136(229)230)151(245)204-124(80-103-50-52-104(223)53-51-103)165(259)215-142(99(23)221)173(267)197-106(45-32-35-65-177)147(241)189-105(44-31-34-64-176)149(243)201-119(74-91(9)10)160(254)198-114(143(181)237)81-133(180)225;3-2(4,5)1(6)7/h25-30,40-43,50-53,87-99,105-131,140-142,218-221,223H,31-39,44-49,54-86,176-178H2,1-24H3,(H2,179,224)(H2,180,225)(H2,181,237)(H,185,240)(H,186,260)(H,187,263)(H,188,226)(H,189,241)(H,190,256)(H,191,252)(H,192,242)(H,193,244)(H,194,250)(H,195,251)(H,196,253)(H,197,267)(H,198,254)(H,199,238)(H,200,239)(H,201,243)(H,202,257)(H,203,258)(H,204,245)(H,205,261)(H,206,262)(H,207,246)(H,208,265)(H,209,249)(H,210,247)(H,211,255)(H,212,266)(H,213,248)(H,214,264)(H,215,259)(H,227,228)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H4,182,183,184);(H,6,7)/t97-,98-,99+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,140-,141-,142-;/m0./s1
InChi Key
CGPWSFMOHMMWPK-NWIWYQHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    RG33 is a 33-amino acid synthetic peptide that corresponds to amino acids 209-219 and 220-241 of the two class Y helices in the C-terminal domain of apolipoprotein A1 (ApoA1).1 It solubilizes multilamellar vesicles (MLVs) containing 1,2-dimyristoyl-sn-glycero-3-PC (DMPC; Item No. 15097) to form recombinant HDL. Lipid-bound RG33 induces cholesterol efflux in J774 macrophages. RG33 (12 mg/kg) decreases blood glucose levels in insulin-resistant mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edmunds, S.J., Liébana-García, R., Stenkula, K.G., et al. A short peptide of the C-terminal class Y helices of apolipoprotein A-I has preserved functions in cholesterol efflux and in vivo metabolic control. Sci. Rep. 10(1), 18070 (2020).