A metabolite of tryptophan
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Indole-3-lactic Acid

Item No. 37534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-hydroxy-1H-indole-3-propanoic acid
CAS Number
1821-52-9
Synonyms
  • DL-Indole-3-lactic Acid
  • ILA
Molecular Formula
C11H11NO3
Formula Weight
205.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
λmax
222 nm
SMILES
O=C(C(CC1=CNC2=C1C=CC=C2)O)O
InChi Code
InChI=1S/C11H11NO3/c13-10(11(14)15)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,10,12-13H,5H2,(H,14,15)
InChi Key
XGILAAMKEQUXLS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $44

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    100 mg

    $80

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    500 mg

    $263

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    Cayman Chemical
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    Product Description

    Indole-3-lactic acid is a metabolite of tryptophan (Item Nos. 31210 | 29600).1 It is formed from tryptophan by gut microbiota. Indole-3-lactic acid (0.1-10 mM) inhibits LPS-induced production of IL-8 in Caco-2 intestinal epithelial cells. It reduces colon tumor number and size in cancer-prone Apc+/Min mice when administered at a dose of 20 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ehrlich, A.M., Pacheco, A.R., Henrick, B.M., et al. Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. BMC Microbiol. 20(1), 357 (2020).

    2. Sugimura, N., Li, Q., Chu, E.S.H., et al. Lactobacillus gallinarum modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis. Gut 71(10), 2011-2021 (2021).