An NR4A1 antagonist
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DIM-C-pPhCO2Me

Item No. 37540

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(di-1H-indol-3-ylmethyl)-benzoic acid, methyl ester
CAS Number
151358-48-4
Molecular Formula
C25H20N2O2
Formula Weight
380.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/ml
SMILES
O=C(C1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1)OC
InChi Code
InChI=1S/C25H20N2O2/c1-29-25(28)17-12-10-16(11-13-17)24(20-14-26-22-8-4-2-6-18(20)22)21-15-27-23-9-5-3-7-19(21)23/h2-15,24,26-27H,1H3
InChi Key
BBAOKSZCULLDIW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $112

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    25 mg

    $186

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    50 mg

    $341

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    Cayman Chemical
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    Product Description

    DIM-C-pPhCO2Me is a nerve growth factor IB (NR4A1) antagonist.1 It decreases expression of the mRNA encoding integrin β1 (ITGB1) in MIA PaCa-2 and PANC-1 pancreatic and RKO and SW480 colon cancer cells when used at concentrations of 15 and 20 µM. DIM-C-pPhCO2Me (15 and 20 µM) decreases the migration and adhesion of MIA PaCa-2 and SW480 cells, effects that can be prevented by siRNA knockdown of NR4A1 or ITGB1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hedrick, E., Lee, S.-O., and Safe, S. The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists. Mol. Carcinog. 56(9), 2066-2075 (2017).