A mGluR1 allosteric antagonist
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CFMTI

Item No. 37546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
CAS Number
864864-17-5
Molecular Formula
C19H16FN5O
Formula Weight
349.4
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlDMF: 1 mg/mlDMSO: Slightly soluble
λmax
272 nm
SMILES
FC1=C(N2N=NC(C3=CC(CN(C4CC4)C5=O)=C5C=C3)=C2C)C=CC=N1
InChi Code
InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3
InChi Key
XZBFQWRAIYRPPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $112

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    10 mg

    $201

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    25 mg

    $417

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    50 mg

    $723

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    Product Description

    CFMTI is a metabotropic glutamate receptor 1 (mGluR1) allosteric antagonist (IC50 = 2.6 nM in CHO cells expressing the human receptor).1,2 It is selective for mGluR1 over mGluR5 by greater than 2,000-fold, as well as over mGluR2, -4, -6, -7, or -8 at 10 µM in CHO cells expressing the human receptors.2 CFTMI reduces methamphetamine-induced hyperlocomotion in mice when administered orally at doses ranging from 1 to 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, S., Hirata, Y., Nagatomi, Y., et al. Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders. Bioorg. Med. Chem. Lett. 19(18), 5310-5313 (2009).

    2. Satow, A., Suzuki, G., Maehara, S., et al. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one. J. Pharmacol. Exp. Ther. 330(1), 179-190 (2009).