A mGluR1 allosteric antagonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CFMTI

Item No. 37546

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
CAS Number
864864-17-5
Molecular Formula
C19H16FN5O
Formula Weight
349.4
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/mlDMF: 1 mg/mlDMSO: Slightly soluble
λmax
272 nm
SMILES
FC1=C(N2N=NC(C3=CC(CN(C4CC4)C5=O)=C5C=C3)=C2C)C=CC=N1
InChi Code
InChI=1S/C19H16FN5O/c1-11-17(22-23-25(11)16-3-2-8-21-18(16)20)12-4-7-15-13(9-12)10-24(19(15)26)14-5-6-14/h2-4,7-9,14H,5-6,10H2,1H3
InChi Key
XZBFQWRAIYRPPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $112

    Add

    10 mg

    $201

    Add

    25 mg

    $417

    Add

    50 mg

    $723

    Add
    Product Description

    CFMTI is a metabotropic glutamate receptor 1 (mGluR1) allosteric antagonist (IC50 = 2.6 nM in CHO cells expressing the human receptor).1,2 It is selective for mGluR1 over mGluR5 by greater than 2,000-fold, as well as over mGluR2, -4, -6, -7, or -8 at 10 µM in CHO cells expressing the human receptors.2 CFTMI reduces methamphetamine-induced hyperlocomotion in mice when administered orally at doses ranging from 1 to 10 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, S., Hirata, Y., Nagatomi, Y., et al. Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: A potential treatment for psychotic disorders. Bioorg. Med. Chem. Lett. 19(18), 5310-5313 (2009).

    2. Satow, A., Suzuki, G., Maehara, S., et al. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one. J. Pharmacol. Exp. Ther. 330(1), 179-190 (2009).