An NSAID and COX inhibitor
Related Products
Alternative(s)
70290(+)-Naproxen
Metabolite(s)
34199(S)-O-Desmethyl Naproxen
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(+)-Naproxen (sodium salt)

Item No. 37554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-6-methoxy-α-methyl-2-naphthaleneacetic acid, monosodium salt
CAS Number
26159-34-2
Synonyms
  • CG 3117
  • (S)-Naproxen
Molecular Formula
C14H13O3 • Na
Formula Weight
252.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: Slightly solubleMethanol: Soluble
SMILES
[O-]C([C@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C)=O.[Na+]
InChi Code
InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
InChi Key
CDBRNDSHEYLDJV-FVGYRXGTSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 g

    $66

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    25 g

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    50 g

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    Product Description

    (+)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor.1 It inhibits COX-1 and COX-2 in COS-1 cells expressing the human enzymes (IC50s = 4.8 and 28.4 µM, respectively). (+)-Naproxen inhibits thromboxane B2 (TXB2; Item No. 19030) and prostaglandin E2 (PGE2; Item No. 14010) production ex vivo in isolated rat blood (IC50s = 5 and 13 µM, respectively).2 Formulations containing (+)-naproxen have been used in the treatment of arthritis, osteoarthritis, gout, and ankylosing spondylitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laneuville, O., Breuer, D.K., DeWitt, D.L., et al. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271(2), 927-934 (1994).

    2. Krekels, E.H.J., Angesjö, M., Sjögren, I., et al. Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats. Pharm. Res. 28(7), 1561-1576 (2011).