An inhibitor of VEGFR2, FGFR1, and FGFR3
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JK-P3

Item No. 37555

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
CAS Number
942655-44-9
Molecular Formula
C18H17N3O3
Formula Weight
323.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/ml
SMILES
O=C(C1=CC=C(C(OC)=C1)OC)NC2=NNC(C3=CC=CC=C3)=C2
InChi Code
InChI=1S/C18H17N3O3/c1-23-15-9-8-13(10-16(15)24-2)18(22)19-17-11-14(20-21-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H2,19,20,21,22)
InChi Key
QAZJUVDICQNITG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $77

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    10 mg

    $146

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    25 mg

    $345

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    50 mg

    $611

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    Product Description

    JK-P3 is an inhibitor of the tyrosine kinases VEGFR2, FGFR1, and FGFR3 (IC50s = 7.83, 27, and 5.18 µM, respectively).1 It decreases VEGF-A-induced VEGFR2 phosphorylation in human umbilical vein endothelial cells (HUVECs) when used at a concentration 10 µM. JK-P3 decreases the proliferation of HCT116, SW480, and HT-29 colon cancer cells (IC50s = 24.26, 27.2, and 29.65 µM, respectively), as well as A549 lung cancer cells (IC50 = 30.49 µM).2 It decreases wound closure percentage in a scratch assay, as well as endothelial branch length and branch points formed by VEGF-A-stimulated HUVECs when used at a concentration of 10 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kankanala, J., Latham, A.M., Johnson, A.P., et al. A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br. J. Pharmacol. 166(2), 737-748 (2012).

    2. Dong, Y., Liu, M., Mao, Y., et al. Discovery of 2-(isoxazol-5-yl)phenyl 3,4-dihydroxybenzoate as a potential inhibitor for the Wnt/β-catenin pathway. Bioorg. Chem. 128, 106116 (2022).