MK-8722

MK-8722 is an activator of AMP-activated protein kinase (AMPK).¹ It activates Ampk and increases phosphorylated acetyl-CoA carboxylase 1 (Acc1) levels in primary mouse dorsal root ganglia (DRG) when used at concentrations of 0.1 and 10 µM. MK-8722 (20 and 50 µM) reduces the proliferation, colony formation, migration, and invasion of, and induces apoptosis in, PANC-1 and PaTu 8988 pancreatic cancer cells.² It induces cell cycle arrest at the G₂ phase in PANC-1 and PaTu 8988 cancer cells when used at a concentration of 50 µM. In vivo, MK-8722 (25 mg/kg per day) reduces tumor volume and weight in a PANC-1 mouse xenograft model. It decreases blood glucose levels in fasting and glucose-challenged mice in a mouse model of diabetes induced by a high-fat diet when administered at doses of 10 and 30 mg/kg.³ MK-8722 (30 mg/kg) increases the paw withdrawal threshold in the von Frey test in mice.¹

WARNING This product is not for human or veterinary use.

1. Inyang, K.E., Burton, M.D., Szabo-Pardi, T., et al. Indirect AMP-activated protein kinase activators prevent incision-induced hyperalgesia and block hyperalgesic priming, whereas positive allosteric modulators block only priming in mice. J. Pharmacol. Exp. Ther. 371(1), 138-150 (2023).

2. Wang, C., Huang, B., Sun, L., et al. MK8722, an AMPK activator, inhibiting carcinoma proliferation, invasion and migration in human pancreatic cancer cells. Biomed. Pharmacother. 144, 112325 (2021).

3. Feng, D., Biftu, T., Romero, F.A., et al. Discovery of MK-8722: A systemic, direct pan-activator of AMP-activated protein kinase. ACS Med. Chem. Lett. 9(1), 39-44 (2017).