An inhibitor of the CF5-Dvl protein-protein interaction
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KY 19382

Item No. 37579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
CAS Number
2226664-93-1
Molecular Formula
C17H11Cl2N3O2
Formula Weight
360.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1NC2=C(C1=C3NC4=C(C3=NOC)C=CC=C4)C=C(Cl)C(Cl)=C2
InChi Code
InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23)
InChi Key
PROTUMHDKVZVBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $260

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    10 mg

    $423

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    Product Description

    KY 19382 is an inhibitor of the protein-protein interaction between CXXC-type zinc finger protein 5 (CF5) and Dishevelled (Dvl; IC50 = 19 nM).1 It is also an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 10 nM). KY 19382 (100 nM) increases expression of the mRNA encoding Wnt1-inducible signaling pathway protein 1 (WISP-1) and Axin2, markers of Wnt pathway activation, in ATDC-5 chondrogenic cells and increases nuclear and cytosolic levels of β-catenin in the same cells. KY 19382 (0.1 mg/kg per day) increases bone plate growth and tibia length in adolescent mice. It increases β-catenin levels in primary human dermal papilla cells, and topical application of KY 19382 promotes hair regrowth in normal and diabetic mice.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, S., Kim, H.-Y., Cha, P.-H., et al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci. Alliance 2(2), e201800254 (2019).

    2. Ryu, Y.C., Lee, D.H., Shim, J., et al. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br. J. Pharmacol. 178(12), 2533-2546 (2021).

    3. Ryu, Y.C., Kim, Y.-R., Park, J., et al. Wnt/β-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus. BMB Rep. 55(11), 559-564 (2022).