An inhibitor of the CF5-Dvl protein-protein interaction
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KY 19382

Item No. 37579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
CAS Number
2226664-93-1
Molecular Formula
C17H11Cl2N3O2
Formula Weight
360.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1NC2=C(C1=C3NC4=C(C3=NOC)C=CC=C4)C=C(Cl)C(Cl)=C2
InChi Code
InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23)
InChi Key
PROTUMHDKVZVBW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $65

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    5 mg

    $260

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    10 mg

    $423

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    Product Description

    KY 19382 is an inhibitor of the protein-protein interaction between CXXC-type zinc finger protein 5 (CF5) and Dishevelled (Dvl; IC50 = 19 nM).1 It is also an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 10 nM). KY 19382 (100 nM) increases expression of the mRNA encoding Wnt1-inducible signaling pathway protein 1 (WISP-1) and Axin2, markers of Wnt pathway activation, in ATDC-5 chondrogenic cells. It increases nuclear and cytosolic levels of β-catenin in ATDC-5 cells when used at a concentration of 100 nM. KY 19382 (0.1 mg/kg per day) increases bone plate growth and tibia length in adolescent mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choi, S., Kim, H.-Y., Cha, P.-H., et al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci. Alliance 2(2), e201800254 (2019).