A biotinylated mutant vimentin peptide
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Vimentin (G147R) (140-160)-biotin Peptide

Item No. 37623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Biotin-GQGKSRLRDLYEEEMRELRRQ
  • VIM (G147R) (140-160)-biotin
Purity
≥95%
MW
2,876.25
Formulation (Request formulation change)
A solid
UniProt Accession №
P08670
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $247

    Add
    Cayman Chemical
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    Product Description

    Vimentin (G147R) (140-160)-biotin peptide is a biotinylated version of a mutant isoform of the cytoskeleton intermediate filament protein vimentin, vimentinG146R, which undergoes citrullination and has been found as the citrullinated form in the synovial fluid of rheumatoid arthritis patients.1 Vimentin is subject to citrullination by peptidyl arginine deiminase 2 (PAD2) under high calcium concentrations, which can occur during macrophage apoptosis.2,3 Cayman’s Vimentin (G147R) (140-160)-biotin Peptide is intended for use as a negative control in the detection of autoantibodies against citrullinated vimentinG146R and is the non-citrullinated form of Citrullinated Vimentin (G146R) (R144 + R146) (139-159)-biotin Peptide (Item No. 37625).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bang, H., Egerer, K., Gauliard, A., et al. Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis. Arthritis Rheum. 56(8), 2503-2511 (2007).

    2. Li, F.J., Surolia, R., Li, H., et al. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci. Transl. Med. 13(585), eaba2927 (2021).

    3. Asaga, H., Yamada, M., and Senshu, T. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem. Biophys. Res. Commun. 243(3), 641-646 (1998).