A soluble adenylyl cyclase inhibitor
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TDI-10229

Item No. 37674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-6-[1,5-dimethyl-4-(phenylmethyl)-1H-pyrazol-3-yl]-2-pyrimidinamine
CAS Number
2810887-45-5
Molecular Formula
C16H16ClN5
Formula Weight
313.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 1 mg/ml
λmax
213, 215 nm
SMILES
NC1=NC(Cl)=CC(C2=NN(C)C(C)=C2CC3=CC=CC=C3)=N1
InChi Code
InChI=1S/C16H16ClN5/c1-10-12(8-11-6-4-3-5-7-11)15(21-22(10)2)13-9-14(17)20-16(18)19-13/h3-7,9H,8H2,1-2H3,(H2,18,19,20)
InChi Key
VSMTYSWGHKYXOF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $33

    Add

    5 mg

    $131

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    10 mg

    $213

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    25 mg

    $489

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    Product Description

    TDI-10229 is an inhibitor of soluble adenylyl cyclase (sAC; IC50 = 0.2 µM for the human enzyme in a cell-free assay).1 It is selective for sAC over the transmembrane ACs AC1-3, -5, -8, and -9 at 10 µM. TDI-10229 inhibits cAMP accumulation induced by the phosphodiesterase (PDE) inhibitor IBMX (Item No. 13347) in rodent sAC-expressing HEK293 cells (IC50 = 0.1 µM). It also inhibits capacitation-induced cAMP accumulation and protein kinase A (PKA) activation in isolated mouse and human sperm when used at a concentration of 5 µM. TDI-10229 (5 and 50 µM) prevents the acrosome reaction and fertilization of mouse sperm with mouse oocytes in vitro.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balbach, M., Ghanem, L., Rossetti, T., et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization. Mol. Hum. Reprod. 27(9), gaab054 (2021).