An irreversible inhibitor of BTK
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Tolebrutinib

Item No. 37723

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one
CAS Number
1971920-73-6
Molecular Formula
C26H25N5O3
Formula Weight
455.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
222 nm
SMILES
NC1=C2C(N([C@@]3([H])CN(CCC3)C(C=C)=O)C(N2C4=CC=C(C=C4)OC5=CC=CC=C5)=O)=CC=N1
InChi Code
InChI=1S/C26H25N5O3/c1-2-23(32)29-16-6-7-19(17-29)30-22-14-15-28-25(27)24(22)31(26(30)33)18-10-12-21(13-11-18)34-20-8-4-3-5-9-20/h2-5,8-15,19H,1,6-7,16-17H2,(H2,27,28)/t19-/m1/s1
InChi Key
KOEUOFPEZFUWRF-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $76

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    10 mg

    $138

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    25 mg

    $241

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    Product Description

    Tolebrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 1 nM).1 It decreases the number of CD69+ B cells in isolated mouse whole blood (IC50 = 200 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hopkins, B.T., Bame, E., Bajrami, B., et al. Discovery and preclinical characterization of BIIB091, a reversible, selective BTK inhibitor for the treatment of multiple sclerosis. J. Med. Chem. 65(2), 1206-1224 (2022).