A chemical chaperone of glucocerebrosidase
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ML-198

Item No. 37755

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-ethynylphenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS Number
1380716-06-2
Synonyms
  • NCGC758
Molecular Formula
C17H14N4O
Formula Weight
290.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
215, 244, 293 nm
SMILES
O=C(C1=C(N=C(C)C=C2C)N2N=C1)NC3=CC=C(C=C3)C#C
InChi Code
InChI=1S/C17H14N4O/c1-4-13-5-7-14(8-6-13)20-17(22)15-10-18-21-12(3)9-11(2)19-16(15)21/h1,5-10H,2-3H3,(H,20,22)
InChi Key
HVZPJBKUFRREQC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $198

    Add

    10 mg

    $307

    Add
    Product Description

    ML-198 is a chemical chaperone of glucocerebrosidase.1 It activates hydrolysis of the fluorescent glucocerebrosidase substrate 4-methylumbelliferyl-β-D-glucopyranoside (4-MUG; Item No. 20948) in spleen homogenate isolated from patients with Gaucher disease with the homozygous N370S mutant of glucocerebrosidase (glucocerebrosidaseN370S; AC50 = 0.36 µM). ML-198 (5 µM) increases the translocation of glucocerebrosidaseN370S to lysosomes in dermal fibroblasts isolated from patients with Gaucher disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patnaik, S., Zheng, W., Choi, J.H., et al. Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase. J. Med. Chem. 55(12), 5734-5748 (2012).