An inhibitor of the c-Myc-Max protein-protein interaction
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Product Type

Biochemicals

Research Area

Cancer

Mycro 3

Item No. 37767

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester
CAS Number
944547-46-0
Molecular Formula
C24H17ClF2N6O4
Formula Weight
526.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C1=C(NC(C2=NN3C(N=C(C4=CC=CO4)C=C3C(F)(Cl)F)=C2)=O)N(C5=CC=CC=C5)N=C1)OCC
InChi Code
InChI=1S/C24H17ClF2N6O4/c1-2-36-23(35)15-13-28-32(14-7-4-3-5-8-14)21(15)30-22(34)17-12-20-29-16(18-9-6-10-37-18)11-19(24(25,26)27)33(20)31-17/h3-13H,2H2,1H3,(H,30,34)
InChi Key
YPPNLSKYXDXQGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

    $160

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    5 mg

    $710

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    10 mg

    $1,064

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    Cayman Chemical
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    Product Description

    Mycro 3 is an inhibitor of the protein-protein interaction between c-Myc and c-Myc associated protein (Max; IC50 = 40 µM).1 It is also an inhibitor of Max dimerization (IC50 = 88 µM). Mycro 3 selectively reduces the viability of c-Myc-expressing TGR-1 fibroblasts over c-Myc-null HO15.19 fibroblasts (IC50s = 0.25 and 9 µM, respectively).2 It decreases tumor weight in PANC-1 and MIA PaCa-2 pancreatic cancer mouse xenograft models when administered at a dose of 100 mg/kg per day. Mycro 3 (5 mg/kg every three days), in combination with docetaxel (Item No. 11637) or abiraterone (Item No. 9002768), reduces tumor volume and improves survival in an LNCaP prostate cancer mouse xenograft model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kiessling, A., Wiesinger, R., Sperl, B., et al. Selective inhibition of c-Myc/Max dimerization by a pyrazolo[1,5-a]pyrimidine. ChemMedChem 2(5), 627-630 (2007).

    2. Stellas, D., Szabolcs, M., Koul, S., et al. Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J. Natl. Cancer Inst. 106(12), dju320 (2014).

    3. Li, F., Zhao, Z., Zhang, Z., et al. Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner. BMC Cancer 21(1), 1112 (2021).