A CYP17A1 inhibitor and an active metabolite of abiraterone acetate
Related Products
Active Metabolite(s)
27594Δ4-Abiraterone
Pro-drug Form(s)
15148Abiraterone Acetate 27594Δ4-Abiraterone
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Abiraterone

Item No. 9002768

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β)-17-(3-pyridinyl)-androsta-5,16-dien-3-ol
CAS Number
154229-19-3
Synonyms
  • CB-7598
Molecular Formula
C24H31NO
Formula Weight
349.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 1 mg/mlEthanol: 15 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
254 nm
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CN=CC=C5
InChi Code
InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1
InChi Key
GZOSMCIZMLWJML-VJLLXTKPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Abiraterone is an inhibitor of the cytochrome P450 (CYP) isoform CYP17A1 (IC50s = 0.0029 and 0.004 µM for the 17,20-lyase and 17α-hydroxylase activities, respectively) and active metabolite of abiraterone acetate (Item No. 15148).1,2 It is formed from abiraterone acetate by arylacetamide deacetylase.3 Abiraterone is selective for CYP17A1 over aromatase and 5α-reductase (IC50s = >20 and >50 µM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Potter, G.A., Barrie, S.E., Jarman, M., et al. Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer. J. Med. Chem. 38(13), 2463-2471 (1995).

    2. Barrie, S.E., Potter, G.A., Goddard, P.M., et al. Pharmacology of novel steroidal inhibitors of cytochrome P45017α (17α-hydroxylase/C17-20 lyase). J. Steroid Biochem. Mol. Biol. 50(5-6), 267-273 (1994).

    3. Sakai, Y., Fukami, T., Nagaoka, M., et al. Arylacetamide deacetylase as a determinant of the hydrolysis and activation of abiraterone acetate in mice and humans. Life Sci. 284, 119896 (2021).