A PEGylated derivative of DSG
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DSG-mPEG(2000)

Item No. 37800

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[2,3-bis[(1-oxooctadecyl)oxy]propyl]-ω-methoxy-poly(oxy-1,2-ethanediyl)
CAS Number
308805-39-2
Synonyms
  • 1,2-Distearoyl-rac-glycero-3-methylpolyoxyethylene
Molecular Formula
(C2H4O)nC40H78O5
Formula Weight
386.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
SMILES
COCCOCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $127

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    500 mg

    $216

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    1 g

    $279

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    Cayman Chemical
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    Product Description

    DSG-mPEG(2000) is a PEGylated derivative of 1,2-distearoyl-sn-glycerol (DSG; Item No. 15079).1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). LNPs containing DSG-mPEG(2000) and encapsulating a toll-like receptor 7 (TLR7) and TLR8 agonist and a peptide antigen each conjugated to poly(L-glutamic acid) (PGA) increase the activation of dendritic cells, macrophages, and B cells in the draining lymph node and dendritic cells and B cells in the spleen in mice compared to the non-LNP-encapsulated PGA-conjugated TLR7/8 agonist and peptide antigen.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Lysebetten, D., Malfanti, A., Deswarte, K., et al. Lipid-polyglutamate nanoparticle vaccine platform. ACS Appl. Mater. Interfaces 13(5), 6011-6022 (2021).