A Mas receptor agonist
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AVE-0991

Item No. 37837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(ethylamino)carbonyl]-3-[4-[(5-formyl-4-methoxy-2-phenyl-1H-imidazol-1-yl)methyl]phenyl]-5-(2-methylpropyl)-2-thiophenesulfonamide
CAS Number
304462-19-9
Molecular Formula
C29H32N4O5S2
Formula Weight
580.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
230, 275, 305 nm
SMILES
O=CC1=C(OC)N=C(N1CC2=CC=C(C3=C(S(NC(NCC)=O)(=O)=O)SC(CC(C)C)=C3)C=C2)C4=CC=CC=C4
InChi Code
InChI=1S/C29H32N4O5S2/c1-5-30-29(35)32-40(36,37)28-24(16-23(39-28)15-19(2)3)21-13-11-20(12-14-21)17-33-25(18-34)27(38-4)31-26(33)22-9-7-6-8-10-22/h6-14,16,18-19H,5,15,17H2,1-4H3,(H2,30,32,35)
InChi Key
QTOZBSNPDCWHPV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $57

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    5 mg

    $238

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    10 mg

    $418

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    25 mg

    $765

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    Product Description

    AVE-0991 is an agonist of the Mas receptor, also known as the angiotensin (1-7) receptor.1 It binds to the Mas receptor in bovine aortic endothelial cell membranes and COS cells (IC50s = 21 and 47.5 nM, respectively).2,1 It reduces urinary volume in water-loaded mice, an effect that can be blocked by the angiotensin (1-7) antagonist A-779 (Item No. 23396) and is reduced in Mas knockout mice.1 Dietary administration of AVE-0991 (0.58 µmol/kg per day) inhibits perivascular inflammation and increases plaque stability in an ApoE-/- mouse model of atherosclerosis.3 It also inhibits the formation of abdominal aortic aneurysm induced by angiotensin II in ApoE-/- mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinheiro, S.V.B., Simões e Silva, A.C., Sampaio, W.O., et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension 44(4), 490-496 (2004).

    2. Wiemer, G., Dobrucki, L.W., Louka, F.R., et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension 40(6), 847-852 (2002).

    3. Skiba, D.S., Nosalski, R., Mikolajczyk, T.P., et al. Anti-atherosclerotic effect of the angiotensin 1-7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. Br. J. Pharmacol. 174(22), 4055-4069 (2017).