A GPX4 inhibitor
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LOC1886

Item No. 38026

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-imidazol-1-yl(4-methoxy-1H-indol-2-yl)-methanone
CAS Number
951948-38-2
Molecular Formula
C13H11N3O2
Formula Weight
241.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/ml
λmax
249, 320 nm
SMILES
O=C(N1C=CN=C1)C2=CC3=C(OC)C=CC=C3N2
InChi Code
InChI=1S/C13H11N3O2/c1-18-12-4-2-3-10-9(12)7-11(15-10)13(17)16-6-5-14-8-16/h2-8,15H,1H3
InChi Key
KVCZCNUNOCVNIE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $33

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    5 mg

    $156

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    10 mg

    $294

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    Cayman Chemical
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    Product Description

    LOC1886 is an inhibitor of glutathione peroxidase 4 (GPX4; Ki = 102 µM).1 It covalently binds to GPX4U46C and inhibits GPX4-mediated reduction of phospholipid hydroperoxides in HT-1080 cell lysates when used at a concentration of 100 µM. LOC1886 (100 µM) increases lipid peroxidation in HT-1080 cells, an effect that can be rescued by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H., Forouhar, F., Lin, A.J., et al. Small-molecule allosteric inhibitors of GPX4. Cell Chem. Biol. 29(12), 1680-1693 (2022).