Host: HEK293 cells • AA: 67-277 • Tag: N-terminal His • MW: 21 kDa
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NKR-P1A/CD161 Extracellular Domain (mouse, recombinant)

Item No. 38063

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CD161 Antigen-like Family Member A
  • Killer Cell Lectin-like Receptor Subfamily B Member 1A
  • KLRB1A
  • Natural Killer Cell Receptor P1A
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/µg determined by the LAL endotoxin assay
Source
Recombinant mouse N-terminal His-tagged NKR-P1A extracellular domain expressed in HEK293 cells
Amino Acids
67-277
MW
21 kDa
Formulation (Request formulation change)
Lyophilized from sterile PBS, pH 7.4
UniProt Accession №
P27811
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $383

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    Product Description

    CD161, also known as natural killer (NK) cell receptor P1A (NKR-P1A), is a type II transmembrane protein that is encoded by the Klrb1a gene in mice.1 It is composed of an N-terminal cytoplasmic domain, a transmembrane domain, a stalk region, and an extracellular region that contains the C-type lectin-like domain and is expressed in NK cells and T cells.1,2 NKR-P1A is an inhibitory receptor in humans, which is stimulated by its ligand lectin-like transcript 1 (LLT-1) and signals through the PI3K/Akt/ERK pathway, whereas Nrk-p1a is an activating receptor in mice, which signals through the immunoreceptor tyrosine-based activation motifs (ITAMs) of adaptor proteins.1 Monoclonal antibodies targeting NKR-P1A increase T cell-induced cytotoxicity and decrease programmed cell death protein 1 (PD-1) levels in glioblastoma cells and knockout of KLRB1 increases survival in a humanized mouse model of glioblastoma.3 Levels of NKR-P1A are increased in CD4+ and CD8+ T cells in patients with advanced stage osteoarthritis.4 Cayman’s NKR-P1A/CD161 Extracellular Domain (mouse, recombinant) protein consists of 180 amino acids and has a calculated molecular weight of 21 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 30-35 kDa due to glycosylation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rozbeský, D., Ivanova, L., Hernychová, L., et al. Nkrp1 family, from lectins to protein interacting molecules. Molecules 20(2), 3463-3478 (2015).

    2. Yu, Y.Y.L., Kumar, V., and Bennett, M. Murine natural killer cells and marrow graft rejection. Annu. Rev. Immunol. 10, 189-213 (1992).

    3. Mathewson, N.D., Ashenberg, O., Tirosh, I., et al. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell 184(5), 1281-1298 (2021).

    4. Sachdeva, M., Aggarwal, A., Sharma, R., et al. Chronic inflammation during osteoarthritis is associated with an increased expression of CD161 during advanced stage. Scand. J. Immunol. 90(1), e12770 (2019).