An NSAID, a COX inhibitor, and an active metabolite of loxoprofen
Related Products
Pro-drug Form(s)
35088Loxoprofen (sodium salt)
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Loxoprofen-SRS

Item No. 38122

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[(1R,2S)-2-hydroxycyclopentyl]methyl]-αS-methyl-benzeneacetic acid
CAS Number
83648-76-4
Molecular Formula
C15H20O3
Formula Weight
248.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
C[C@H](C(O)=O)C1=CC=C(C[C@@H]2[C@@H](O)CCC2)C=C1
InChi Code
InChI=1S/C15H20O3/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16/h5-8,10,13-14,16H,2-4,9H2,1H3,(H,17,18)/t10-,13+,14-/m0/s1
InChi Key
SHAHPWSYJFYMRX-GDLCADMTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $125

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    10 mg

    $220

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    25 mg

    $482

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    Product Description

    Loxoprofen-SRS is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.5 and 0.39 for recombinant human COX-1 and COX-2, respectively) and an active metabolite of the prodrug loxoprofen (Item No. 35088).1 Intravenous administration of loxoprofen-SRS inhibits acetic acid-induced writhing, reduces carrageenan-induced mechanical hyperalgesia, and decreases carrageenan-induced paw edema in rats (ED50s = 0.43, 1.28, and 8.01 mg/kg, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riendeau, D., Salem, M., Styhler, A., et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg. Med. Chem. Lett. 14(5), 1201-1203 (2004).

    2. Ye, H., Lv, T., Min, T., et al. HR1405-01, a safe intravenous NSAID with superior anti-inflammatory and analgesic activities in preclinical trials. Eur. J. Med. Chem. 235:114258, (2022).