A phospholipid
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1-Stearoyl-2-Oleoyl-sn-glycero-3-PE

Item No. 38153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z-octadecenoic acid, 1R-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-2-[(1-oxooctadecyl)oxy]ethyl ester
CAS Number
6418-95-7
Synonyms
  • 1-Octadecanoyl-2-(9Z)-Octadecenoyl-sn-glycero-3-Phosphatidylethanolamine
  • 1-Octadecanoyl-2-(9Z)-Octadecenoyl-sn-glycero-3-Phosphoethanolamine
  • 18:0-18:1 PE
  • PE(18:0/18:1)
  • 1-Stearoyl-2-Oleoyl-sn-glycero-3-Phosphoethanolamine
  • 1,2-SOPE
Molecular Formula
C41H80NO8P
Formula Weight
746.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 30 mg/ml
SMILES
O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[NH3+])([O-])=O
InChi Code
InChI=1S/C41H80NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h18,20,39H,3-17,19,21-38,42H2,1-2H3,(H,45,46)/b20-18-/t39-/m1/s1
InChi Key
JQKOHRZNEOQNJE-DJEJVYNPSA-N
Side Chain Carbon Sum
36:1
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $124

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    25 mg

    $293

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
    READ THE ARTICLE
    Product Description

    1-Stearoyl-2-oleoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid (Item No. 10011298) and oleic acid (Item Nos. 90260 | 24659) at the sn-1 and sn-2 positions, respectively. It has been used in the generation of lipid nanoparticles (LNPs) for in vitro delivery of mRNA or nuclear-targeted plasmid DNA.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Álvarez-Benedicto, E., Farbiak, L., Ramírez, M.M., et al. Optimization of phospholipid chemistry for improved lipid nanoparticle (LNP) delivery of messenger RNA (mRNA). Biomater. Sci. 10(2), 549-559 (2022).

    2. Tanaka, H., Akita, H., Ishiba, R., et al. Neutral biodegradable lipid-envelope-type nanoparticle using vitamin A-Scaffold for nuclear targeting of plasmid DNA. Biomaterials 35(5), 1755-1761 (2014).