An internal standard for the quantification of 11-dehydro-2,3-dinor TXB2
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Unlabeled Version(s)
1951011-dehydro-2,3-dinor Thromboxane B2
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11-dehydro-2,3-dinor Thromboxane B2-d9

Item No. 38254

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-5-((2R,3S,4S)-4-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl-5,5,6,6,7,7,8,8,8-d9)-6-oxotetrahydro-2H-pyran-3-yl)pent-3-enoic acid
Synonyms
  • 11-dehydro-2,3-dinor TXB2-d9
Molecular Formula
C18H19D9O6
Formula Weight
349.5
Purity
≥99% deuterated forms (d1-d9)
Formulation
A 100 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 100 mg/mlMethyl Acetate: 1 mg/mlPBS (pH 7.2): 100 μg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])OC(C1)=O
InChi Code
InChI=1S/C18H28O6/c1-2-3-4-7-13(19)10-11-16-14(8-5-6-9-17(21)22)15(20)12-18(23)24-16/h5-6,10-11,13-16,19-20H,2-4,7-9,12H2,1H3,(H,21,22)/b6-5-,11-10+/t13-,14-,15-,16+/m0/s1/i1D3,2D2,3D2,4D2
InChi Key
PJAAKFHMQLYVGV-PAYANANYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $224

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    50 µg

    $403

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    100 µg

    $715

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    Product Description

    11-dehydro-2,3-dinor Thromboxane B2-d9 (11-dehydro-2,3-dinor TXB2-d9) is intended for use as an internal standard for the quantification of 11-dehydro-2,3-dinor TXB2 (Item No. 19510) by GC- or LC-MS. 11-dehydro-2,3-dinor TXB2 is a metabolite of the TXA2 inactive metabolite TXB2 (Item No. 19030).1 It is formed from TXB2 by cytosolic aldehyde dehydrogenase (ALDH) and β-oxidation.1,2 Levels of 11-dehydro-2,3-dinor TXB2 are increased 5.2-fold in a surgery-induced rat model of tendon overuse.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, L.J., II, Sweetman, B.J., and Oates, J.A. Metabolism of thromboxane B2 in Man. Identification of the major urinary metabolite. The Journal of Biological Chemisty 256(16), 8384-8393 (1981).

    2. Westlund, P., Fylling, A.C., Cederlund, E., et al. 11-Hydroxythromboxane B2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase. FEBS Lett. 345(2-3), 99-103 (1994).

    3. Markworth, J.F., Sugg, K.B., Sarver, D.C., et al. Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse. The FASEB Journal 35(6), e21655 (2021).