Ganglioside G_Q1b Monoclonal Antibody (Clone EM6)

Ganglioside G_Q1b is a sialic acid-containing glycosphingolipid that has been found in myelin of the oculomotor nerves and dorsal root ganglia, as well as neuromuscular spindle fibers.^1,2 It is found on the plasma membrane, where it is anchored by the ceramide moiety with the sialylated oligosaccharide on the extracellular side.¹ In axonal myelin, it helps to stabilize the paranodal region in the node of Ranvier.² Ganglioside G_Q1b is similar in shape to lipo-oligosaccharides (LOS) on the membrane of certain pathogens, including the bacterium C. jejuni. Due to this similarity, autoantibodies against ganglioside G_Q1b can be formed during infection with C. jejuni. Autoantibodies against ganglioside G_Q1b are found in the cerebrospinal fluid in a majority of patients during the acute phase of Miller-Fisher syndrome, a rare variant of Guillain-Barré syndrome characterized by eye movement abnormalities, impaired coordination, and tendon reflex loss.^1,3,2 Cayman's Ganglioside G_Q1b Monoclonal Antibody (Clone EM6) can be used for dot blot, ELISA, immunofluorescence (IF), and TLC immunostaining applications.

WARNING This product is not for human or veterinary use.

1. Goodyear, C.S., O'Hanlon, G.M., Plomp, J.J., et al. Monoclonal antibodies raised against Guillain-Barré syndrome-associated Campylobacter jejuni lipopolysaccharides react with neuronal gangliosides and paralyze muscle-nerve preparations. J. Clin. Invest. 104(6), 697-708 (1999).

2. Noioso, C.M., Bevilacqua, L., Acerra, G.M., et al. Miller Fisher syndrome: An updated narrative review. Front. Neurol. 14, 1250774 (2023).

3. Halstead, S.K., Humphreys, P.D., Goodfellow, J.A., et al. Complement inhibition abrogates nerve terminal injury in Miller Fisher syndrome. Ann. Neurol. 58(2), 203-210 (2005).