An inhibitor of SARS-CoV helicase nsp13 and the HPV E6-E6-AP protein-protein interaction
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SSYA10-001

Item No. 38324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione
CAS Number
675104-49-1
Molecular Formula
C12H12N4O2S2
Formula Weight
308.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
252 nm
SMILES
S=C1NN=C(CSC2=C([N+]([O-])=O)C=CC=C2)N1CC=C
InChi Code
InChI=1S/C12H12N4O2S2/c1-2-7-15-11(13-14-12(15)19)8-20-10-6-4-3-5-9(10)16(17)18/h2-6H,1,7-8H2,(H,14,19)
InChi Key
VWFIHGWHMXSTAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    SSYA10-001 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) helicase nsp13 (IC50s = 5.3 and 5.7 µM for dsDNA and dsRNA, respectively) and the protein-protein interaction between human papillomavirus (HPV) E6 and E6-associated proteins (E6-AP; IC50 = 10 µM).1,2,3 It is selective for SARS-CoV nsp13 over hepatitis C virus (HCV) and dengue virus helicases at 2 µM.1 SSYA10-001 inhibits the replication of SARS-CoV in HEK293T cells, Middle East respiratory syndrome CoV (MERS-CoV) in Vero E6 cells, and mouse hepatitis virus (MHV) in mouse WM-L2 fibroblasts (EC50s = 8.95, 25, and 12 µM, respectively).1,2 It decreases HPV E6-induced p53 degradation in SiHa and HeLa cells when used at concentrations of 1, 5, and 10 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adedeji, A.O., Singh, K., Calcaterra, N.E., et al. Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase. Antimicrob Agents Chemother. 56(9), 4718-4728 (2012).

    2. Adedeji, A.O., SIngh, K., Kassim, A., et al. Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. Antimicrob Agents Chemother. 58(8), 4894-4898 (2014).

    3. Malechka, K.A., Fera, D., Schultz, D.C., et al. Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem. Biol. 9(7), 1603-1612 (2014).