A TLR4 antagonist
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MD2-TLR4-I

Item No. 38328

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dichloro-N-[3-(1H-indol-5-yl)-1H-indazol-5-yl]-benzamide
CAS Number
2249801-12-3
Synonyms
  • Myeloid Differentiation Factor 2-Toll-like Receptor 4-I
Molecular Formula
C22H14Cl2N4O
Formula Weight
421.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
242 nm
SMILES
O=C(C1=C(Cl)C=CC=C1Cl)NC2=CC3=C(NN=C3C4=CC5=C(NC=C5)C=C4)C=C2
InChi Code
InChI=1S/C22H14Cl2N4O/c23-16-2-1-3-17(24)20(16)22(29)26-14-5-7-19-15(11-14)21(28-27-19)13-4-6-18-12(10-13)8-9-25-18/h1-11,25H,(H,26,29)(H,27,28)
InChi Key
AZPDJGLJPDRCDQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    MD2-TLR4-I is a toll-like receptor 4 (TLR4) antagonist.1 It inhibits LPS-induced production of TNF-α and IL-6 in primary mouse macrophages (IC50s = 0.89 and 0.53 µM, respectively). MD2-TLR4-I inhibits LPS-induced, TLR4-mediated NF-κB activation in a reporter assay using RAW 264.7 cells. In vivo, MD2-TLR4-I (10 mg/kg) reduces lung macrophage infiltration and prevents lung edema and alveolar thickening in a mouse model of LPS-induced acute lung injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, Z., Chen, L., Yu, P., et al. Discovery of 3-(indol-5-yl)-indazole derivatives as novel myeloid differentiation protein 2/Toll-like receptor 4 antagonists for treatment of acute lung injury. J. Med. Chem. 62(11), 5453-5469 (2019).