An inhibitor of the Hsp70-BAG-3 protein-protein interaction
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JG-98

Item No. 38337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(Z)-[(5E)-5-(6-chloro-3-methyl-2(3H)-benzothiazolylidene)-3-ethyl-4-oxo-2-thiazolidinylidene]methyl]-3-(phenylmethyl)-thiazolium, monochloride
CAS Number
1456551-16-8
Molecular Formula
C24H21ClN3OS3 • Cl
Formula Weight
534.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): Slightly soluble
SMILES
CN1/C(SC2=C1C=CC(Cl)=C2)=C3S/C(N(CC)C\3=O)=C\C4=[N+](CC5=CC=CC=C5)C=CS4.[Cl-]
InChi Code
InChI=1S/C24H21ClN3OS3.ClH/c1-3-28-21(14-20-27(11-12-30-20)15-16-7-5-4-6-8-16)32-22(23(28)29)24-26(2)18-10-9-17(25)13-19(18)31-24;/h4-14H,3,15H2,1-2H3;1H/q+1;/p-1/b24-22+;
InChi Key
AUPPGWXGMILTRB-HDPAMLMOSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    JG-98 is an inhibitor of the protein-protein interaction between Hsp70 and Bcl-2-associated athanogene 3 (BAG-3; IC50 = 1.6 µM) that binds to an allosteric site on Hsp70.1 JG-98 selectively inhibits the proliferation of a variety of cancer cells, including MDA-MB-231 and MCF-7 breast cancer cells, over mouse embryonic fibroblasts (MEFs; EC50s = 0.39, 0.71, and 4.5 µM, respectively). It also reduces aerobic respiration and the mitochondrial membrane potential in 22Rv1 castration-resistant prostate cancer cells and sensitizes 22Rv1 cells to the androgen receptor pathway inhibitors (ARPIs) enzalutamide (Item No. 11596) and abiraterone (Item No. 9002768).2 JG-98 (3 mg/kg every two days) reduces tumor growth in MCF-7 breast cancer and HeLa cervical cancer mouse xenograft models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Colvin, T., Rauch, J.N., et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol. Cancer Ther. 14(3), 642-648 (2015).

    2. Echtenkamp, F.J., Ishida, R., Rivera-Marquez, G.M., et al. Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer. PNAS Nexus 2(4), pgad115 (2023).