An sEH inhibitor
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AR-9281

Item No. 38346

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-acetyl-4-piperidinyl)-N′-tricyclo[3.3.1.13,7]dec-1-yl-urea
CAS Number
913548-29-5
Synonyms
  • APAU
  • UC1153
Molecular Formula
C18H29N3O2
Formula Weight
319.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
SMILES
O=C(NC(CC1)CCN1C(C)=O)NC2(C[C@@H](C3)C4)C[C@@H]4C[C@@H]3C2
InChi Code
InChI=1S/C18H29N3O2/c1-12(22)21-4-2-16(3-5-21)19-17(23)20-18-9-13-6-14(10-18)8-15(7-13)11-18/h13-16H,2-11H2,1H3,(H2,19,20,23)/t13-,14+,15-,18?
InChi Key
HUDQLWBKJOMXSZ-FFRXJBQQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $74

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    10 mg

    $140

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    25 mg

    $257

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    50 mg

    $476

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    Product Description

    AR-9281 is an inhibitor of soluble epoxide hydrolase (sEH; IC50 = 7 nM for the human enzyme).1 It reduces LPS-induced increases in plasma levels of dihydroxyeicosatrienoic acids (DiHETs), prostaglandin E2 (PGE2; Item No. 14010), and PGD2 (Item No. 12010) in rats when administered at a dose of 3 mg/kg.2 AR-9281 (1 and 3 mg/kg) inhibits LPS-induced allodynia in a rat model of inflammatory pain and increases the paw withdrawal threshold in a rat model of diabetic neuropathic pain induced by streptozotocin (Item No. 13104).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, P.D., Tsai, H.J., Do, Z.N., et al. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg. Med. Chem. Lett. 16(19), 5212-5216 (2006).

    2. Wagner, K., Inceoglu, B., Dong, H., et al. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur. J. Pharmacol. 700(1-3), 93-101 (2013).