An agonist of P2Y receptors
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Adenosine-5'-O-(2-thiodiphosphate) (sodium salt)

Item No. 38360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-adenylic acid, anhydride with phosphorothioic acid, trisodium salt
Synonyms
  • ADP-β-S
Molecular Formula
C10H12N5O9P2S • 3Na
Formula Weight
509.2
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@@H](COP(OP([S-])([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H15N5O9P2S.3Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
InChi Key
CBQAEBOGKWYQRX-MSQVLRTGSA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    2.2 mg

    $163

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Adenosine-5'-O-(2-thiodiphosphate) is an agonist of purinergic P2Y receptors.1 It increases glucose-stimulated insulin release in isolated rat pancreas when used at concentrations ranging from 49.5 to 495 nM. Adenosine-5'-O-(2-thiodiphosphate) (1.5 µM) induces vasodilation in isolated rat pancreas and relaxation in isolated rat aortic rings precontracted by serotonin (5-HT; Item No. 14332) with an EC50 value of 0.09 µM.2 It increases insulin secretion and reduces elevated glucose levels in fasted dogs when administered at a dose of 0.1 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bertrand, G., Chapal, J., Puech, R., et al. Adenosine-5'-O-(2-thiodiphosphate) is a potent agonist at P2 purinoceptors mediating insulin secretion from perfused rat pancreas. Br. J. Pharmacol. 102(3), 627-630 (1991).

    2. Saïag, B., Hillaire-Buys, D., Chapal, J., et al. Study of the mechanisms involved in adenosine-5'-O-(2-thiodiphosphate) induced relaxation of rat thoracic aorta and pancreatic vascular bed. Br. J. Pharmacol. 118(3), 804-810 (1996).

    3. Hillaire-Buys, D., Chapal, J., Bertrand, G., et al. Purinergic receptors on insulin-secreting cells. Fundam. Clin. Pharmacol. 8(2), 117-127 (1993).