A dopamine D3 receptor agonist
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Dopamine D3 Receptor Agonist 13a

Item No. 38382

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-3-methoxy-propanamide
CAS Number
2899250-94-1
Molecular Formula
C22H33Cl2N3O2
Formula Weight
442.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleEthanol: 3 mg/ml
λmax
220 nm
SMILES
ClC1=CC=CC(N2CCN(CC[C@H]3CC[C@H](NC(CCOC)=O)CC3)CC2)=C1Cl
InChi Code
InChI=1S/C22H33Cl2N3O2/c1-29-16-10-21(28)25-18-7-5-17(6-8-18)9-11-26-12-14-27(15-13-26)20-4-2-3-19(23)22(20)24/h2-4,17-18H,5-16H2,1H3,(H,25,28)/t17-,18-
InChi Key
NOSXOCMQQISHPL-IYARVYRRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    Dopamine D3 receptor agonist 13a is a dopamine D3 receptor agonist.1 It selectively binds to dopamine D3 over dopamine D1, D2, and D4 receptors (Kis = 0.14, 4,600, 2.85, and 756 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C (Kis = 6, 54, 1.47, and 252 nM, respectively), however, it is a partial agonist of dopamine D2 receptors (EC50 = 2.26 nM in a G protein recruitment assay) and acts as an antagonist at dopamine D3 receptors (IC50 = 4.62 nM). Dopamine D3 receptor agonist 13a (3 mg/kg) reduces cocaine self-administration in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gogarnoiu, E.S., Vogt, C.D., Sanchez, J., et al. Dopamine D3/D2 receptor ligands based on cariprazine for the treatment of psychostimulant use disorders that may be dual diagnosed with affective disorders. J. Med. Chem. 66(3), 1809-1834 (2023).