2,3,7,8-Tetrachlorodibenzofuran

2,3,7,8-Tetrachlorodibenzofuran is a polychlorinated dibenzofuran and dioxin.¹ It is a byproduct in the synthesis of polychlorinated biphenyls and produced by municipal waste incinerators and open burn sites.^1,2 2,3,7,8-Tetrachlorodibenzofuran (1 µg/kg per day) increases hepatic levels of triglycerides, phospholipids, and ceramides and induces hepatic endoplasmic reticulum stress in mice.³ It induces weight loss and mortality in guinea pigs when administered at a dose of 10 µg/kg.⁴ Intraperitoneal administration of 2,3,7,8-tetrachlorodibenzofuran (0.4 mg/kg) increases the number of fetal mice with cleft palates, as well as induces kidney swelling and increases the number of reabsorbed or dead fetuses in pregnant dams.⁵

WARNING This product is not for human or veterinary use.

1. Moron, M., Sundström, G., and Wachtmeister, C.A. Polycholorinated biphenyls. VI. 2,3,7,8-tetrachlorodibenzofuran, a critical byproduct in the synthesis of 2,2',4,4',5,5'-hexachlorobiphenyl by the Ullmann reaction. Acta Chem. Scand. 27(8), 3121-3122 (1973).

2. Harnly, M., Stephens, R., McLaughlin, C., et al. Polychlorinated dibenzo-p-dioxin and dibenzofuran contamination at metal recovery facilities, open burn sites, and a railroad car incineration facility. Environ. Sci. Technol. 29(3), 667-684 (1995).

3. Yuan, P., Dong, M., Lei, H., et al. Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. Environ. Pollut. 259, 113820 (2020).

4. Ioannou, Y.M., Birnbaum, L.S., and Matthews, H.B. Toxicity and distribution of 2,3,7,8-tetrachlorodibenzofuran in male guinea pigs. J. Toxicol. Environ. Health 12(4-6), 541-553 (1983).

5. Hassoun, E., d'Argy, R., and Dencker, L. Teratogenicity of 2,3,7,8‐tetrachlorodibenzofuran in the mouse. J. Toxicol. Environ. Health 14(2-3), 337-351 (1984).