A PAF receptor antagonist
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LAU-0901

Item No. 38414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid, 3-[2-(3,4-dichlorophenoxy)ethyl] 5-[2-(4-morpholinyl)-1-(4-morpholinylmethyl)ethyl] ester
CAS Number
727358-25-0
Molecular Formula
C29H39Cl2N3O7
Formula Weight
612.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C1=C(C)NC(C)=C(C1C)C(OC(CN2CCOCC2)CN3CCOCC3)=O)OCCOC4=CC=C(C(Cl)=C4)Cl
InChi Code
InChI=1S/C29H39Cl2N3O7/c1-19-26(28(35)40-15-14-39-22-4-5-24(30)25(31)16-22)20(2)32-21(3)27(19)29(36)41-23(17-33-6-10-37-11-7-33)18-34-8-12-38-13-9-34/h4-5,16,19,23,32H,6-15,17-18H2,1-3H3
InChi Key
WZWJKBCMEZITJW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Product Description

    LAU-0901 is a platelet-activating factor (PAF) receptor antagonist.1,2 In vivo, LAU-0901 (30, 60, and 90 mg/kg) reduces infarct volume and improves neurological function in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).1 It also reduces microglial infiltration and increases astrocytic and neuronal survival in the same model.2 LAU-0901 (30 mg/kg) alone, or in combination with atorvastatin (Item No. 10453), reduces tumor growth in a U87MG glioblastoma mouse orthotopic tumor model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Belayev, L., Khoutorova, L., Atkins, K., et al. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp. Neurol. 214(2), 253-258 (2008).

    2. Belayev, L., Eady, T.N., Khoutorova, L., et al. Superior neuroprotective efficacy of LAU-0901, a novel platelet-activating factor antagonist, in experimental stroke. Transl. Stroke Res. 3(1), 154-163 (2012).

    3. Cruz Flores, V.A., Menghani, H., Mukherjee, P.K., et al. Combined therapy with avastin, a PAF receptor antagonist and a lipid mediator inhibited glioblastoma tumor growth. Front. Pharmacol. 12, 746470 (2021).