A PORCN inhibitor
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IWP-O1

Item No. 38418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-phenyl-N-(5-phenyl-2-pyridinyl)-4-(4-pyridinyl)-1H-1,2,3-triazole-1-acetamide
CAS Number
2074607-48-8
Synonyms
  • Inhibitor of Wnt Production-O1
Molecular Formula
C26H20N6O
Formula Weight
432.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
268 nm
SMILES
O=C(CN1N=NC(C2=CC=NC=C2)=C1C3=CC=CC=C3)NC4=CC=C(C5=CC=CC=C5)C=N4
InChi Code
InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
InChi Key
GYYDQHBKIHQHEB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $130

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    10 mg

    $247

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    25 mg

    $582

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    Product Description

    IWP-O1 is an inhibitor of porcupine (PORCN), an enzyme that catalyzes palmitoylation of Wnt proteins.1 It inhibits Wnt signaling in L-Wnt-STF cells (IC50 = 80 pM in a reporter assay) and phosphorylation of Dishevelled-2 (Dvl2) and Dvl3 in HeLa cells when used at a concentration of 1 µM. IWP-O1 (1 µM) enhances the cytotoxicity of the glycolysis inhibitors 2-deoxyglucose (2-DG) and lonidamine (Item No. 14640) in CAL 27 oral squamous cell carcinoma (OSCC) cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. You, L., Zhang, C., Yarravarapu, N., et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg. Med. Chem. Lett. 26(24), 5891-5895 (2016).

    2. Kleszcz, R., and Paluszczak, J. The Wnt signaling pathway inhibitors improve the therapeutic activity of glycolysis modulators against tongue cancer cells. Int. J. Mol. Sci. 23(3), 1248 (2022).