An EP1 receptor antagonist
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ONO-8711 (dicyclohexylamine salt)

Item No. 38432

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid, dicyclohexylamine salt
Molecular Formula
C22H30ClNO4S • C12H23N
Formula Weight
621.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
ClC1=CC(C)=C(S(NC[C@@H](C2CCC3CC2)[C@H]3/C=C\CCCC(O)=O)(=O)=O)C=C1.C4(NC5CCCCC5)CCCCC4
InChi Code
InChI=1S/C22H30ClNO4S.C12H23N/c1-15-13-18(23)11-12-21(15)29(27,28)24-14-20-17-9-7-16(8-10-17)19(20)5-3-2-4-6-22(25)26;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h3,5,11-13,16-17,19-20,24H,2,4,6-10,14H2,1H3,(H,25,26);11-13H,1-10H2/b5-3-;/t16?,17?,19-,20-;/m0./s1
InChi Key
LLFSWESJGDSALX-YBAOTWTCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $372

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    10 mg

    $702

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    25 mg

    $1,445

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    Product Description

    ONO-8711 is an antagonist of the prostaglandin E2 (PGE2; Item No. 14010) receptor subtype EP1 (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells).1 It is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells). ONO-8711 inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively). Dietary administration of ONO-8711 (400 and 800 ppm) reduces the incidence of squamous cell carcinoma and severe dysplasia in a rat model of tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, K., Kawamori, T., Nakatsugi, S., et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res. 59(20), 5093-5096 (1999).

    2. Makita, H., Mutoh, M., Maruyama, T., et al. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis 28(3), 677-684 (2007).