A CYP1B1 inhibitor
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DMU2105

Item No. 38522

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2-naphthalenyl)-1-(3-pyridinyl)-2-propen-1-one
CAS Number
1031063-36-1
Molecular Formula
C18H13NO
Formula Weight
259.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C(C1=CN=CC=C1)C=CC2=CC3=C(C=CC=C3)C=C2
InChi Code
InChI=1S/C18H13NO/c20-18(17-6-3-11-19-13-17)10-8-14-7-9-15-4-1-2-5-16(15)12-14/h1-13H
InChi Key
VWBDGXJRQZDLRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $74

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    10 mg

    $132

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    25 mg

    $238

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    50 mg

    $403

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    Cayman Chemical
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    Product Description

    DMU2105 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.01 µM).1 It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.742, 1.2, 18, and 10 µM, respectively). DMU2105 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horley, N.J., Beresford, K.J.M., Chawla, T., et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur. J. Med. Chem. 129, 159-174 (2017).