An inhibitor of the UHRF1-DNMT1 protein-protein interaction
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

NSC 232003

Item No. 38523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[1-(hydroxyamino)ethylidene]-2,4(3H,5H)-pyrimidinedione
CAS Number
1905453-18-0
Molecular Formula
C6H7N3O3
Formula Weight
169.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C1N=CC(C(N1)=O)=C(C)NO
InChi Code
InChI=1S/C6H7N3O3/c1-3(9-12)4-2-7-6(11)8-5(4)10/h2,9,12H,1H3,(H,8,10,11)
InChi Key
IXSSYZRLNVZFMP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $44

    Add

    5 mg

    $198

    Add

    10 mg

    $351

    Add

    25 mg

    $767

    Add
    Product Description

    NSC 232003 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase UHRF1 and DNA methyltransferase 1 (DNMT1; IC50 = 15 µM in U251 glioma cells).1 It decreases 5-methylcytosine (5-mC) levels in U251 cells (IC50 = 15 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Myrianthopoulos, V., Cartron, P.F., Liutkevičiūtė, Z., et al. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. Eur. J. Med. Chem. 114, 390-396 (2016).