A neutral lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DNCA

Item No. 38554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-[2,3-bis[(9Z)-9-octadecen-1-yloxy]propyl]-2-oxo-1(2H)-pyrimidineacetamide
CAS Number
2226561-66-4
Molecular Formula
C45H82N4O4
Formula Weight
743.2
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/ml
SMILES
NC1=NC(N(CC(NCC(COCCCCCCCC/C=C\CCCCCCCC)OCCCCCCCC/C=C\CCCCCCCC)=O)C=C1)=O
InChi Code
InChI=1S/C45H82N4O4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-37-52-41-42(39-47-44(50)40-49-36-35-43(46)48-45(49)51)53-38-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,35-36,42H,3-16,21-34,37-41H2,1-2H3,(H,47,50)(H2,46,48,51)/b19-17-,20-18-
InChi Key
YFNQKYRJAJXRSL-CLFAGFIQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $219

    Add

    5 mg

    $657

    Add

    10 mg

    $986

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    DNCA is a neutral lipid that has been used in the generation of lipid nanoparticles (LNPs).1 Intravenous administration of LNPs containing DNCA and encapsulating siRNA targeting BRAF containing a valine-to-glutamate substitution at position 600 (BRAFV600E) reduce tumor BRAFV600E expression and tumor weight and volume without reducing animal weight in an A375 melanoma mouse xenograft model. Intratumoral administration of LNPs containing DNCA and encapsulating cyclic di-GMP (Item No. 17144) decreases tumor volume, increase survival, and increase the ratio of tumor-associated cytotoxic/exhausted CD4+ and CD8+ T cells in an EO771 murine model of primary breast cancer with tumor rechallenge.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, X., Pan, Y., Li, Z., et al. siRNA packaged with neutral cytidinyl/cationic/PEG lipids for enhanced antitumor efficiency and safety in vitro and in vivo. ACS Appl. Bio Mater. 3(9), 6297-6309 (2020).

    2. Yu, X., Yu, J., Dai, H., et al. Novel formulation of c-di-GMP with cytidinyl/cationic lipid reverses T cell exhaustion and activates stronger anti-tumor immunity. Theranostics 12(15), 6723-6739 (2022).