An Analytical Reference Standard
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16477Tizanidine (hydrochloride)
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Tizanidine (hydrochloride)

Item No. 38559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • DS 103-282
Technical Information
Formal Name
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, monohydrochloride
CAS Number
64461-82-1
Molecular Formula
C9H8ClN5S • HCl
Formula Weight
290.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 20 mg/mlWater: 10 mg/ml
λmax
227, 320 nm
SMILES
ClC1=C(NC2=NCCN2)C3=NSN=C3C=C1.Cl
InChi Code
InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
InChi Key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Tizanidine (hydrochloride) (Item No. 38559) is an analytical reference standard categorized as a muscle relaxant.1,2 Tizanidine inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats.2 It has been associated with fatal overdoses.3 Formulations containing tizanidine have been used in the treatment of spasticity. This product is intended for analytical forensic applications. This product is also available as a general research tool (Item No. 16477).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakitani, K. The effects of centrally acting muscle relaxants on the intrathecal noradrenaline-induced facilitation of the flexor reflex mediated by group II afferent fibers in rats. Jpn. J. Pharmacol. 63(3), 369-376 (1993).

    2. Sayers, A.C., Bürki, H.R., and Eichenberger, E. The pharmacology of 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole (DS 103-282), a novel myotonolytic agent. Arzneimittelforschung 30(5), 793-803 (1980).

    3. Sklerov, J.H., Cox, D.E., Moore, K.A., et al. Tizanidine distribution in a postmortem case. J. Anal. Toxicol. 30(5), 331-334 (2006).