A polychlorinated dibenzodioxin
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1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin

Item No. 38594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4,7,8-hexachloro-dibenzo[b,e][1,4]dioxin
CAS Number
39227-28-6
Synonyms
  • 1,2,3,4,7,8-HxCDD
  • PCDD 66
Molecular Formula
C12H2Cl6O2
Formula Weight
390.9
Purity
≥98%
Formulation
A solution in n-nonane:toluene (70:30)
Solubility(Learn about Variance in Solubility)
Nonane: Toluene (70:30): Soluble
SMILES
ClC1=C(Cl)C=C2OC3=C(C(Cl)=C(C(Cl)=C3Cl)Cl)OC2=C1
InChi Code
InChI=1S/C12H2Cl6O2/c13-3-1-5-6(2-4(3)14)20-12-10(18)8(16)7(15)9(17)11(12)19-5/h1-2H
InChi Key
WCYYQNSQJHPVMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    60 µg

    $534

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    Cayman Chemical
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    Product Description

    1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin is a polychlorinated dibenzodioxin (PCDD). It induces the activity of aryl hydrocarbon hydroxylase (AHH) when used at a concentration of 47 pmol/egg in chicken embryo livers.1 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin induces toxicity in rats (LD50 = 1.871 mg/kg).2 It has been found in freshwater fish and in the air near municipal waste incinerators.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Poland, A., and Glover, E. Studies on the mechanism of toxicity of the chlorinated dibenzo-p-dioxins. Environ. Health Perspect. 5, 245-251 (1973).

    2. Pohjanvirta, R., Unkila, M., and Tuomisto, J. Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in the most TCDD-susceptible and the most TCDD-resistant rat strain. Pharmacol. Toxicol. 73(1), 52-56 (1993).

    3. Zacharewski, T., Safe, L., Safe, S., et al. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in-vitro enzyme induction activities. Environ. Sci. Technol. 23(6), 730-735 (1989).

    4. Hu, S.-W., ChangChien, G.-P., and Chan, C.-C. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere 55(4), 611-620 (2004).