A dioxin-like polychlorinated dibenzofuran
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1,2,3,6,7,8-Hexachlorodibenzofuran

Item No. 38621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
57117-44-9
Synonyms
  • 1,2,3,6,7,8-HxCDF
  • PCDF 121
Molecular Formula
C12H2Cl6O
Formula Weight
374.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly solubleEthyl Acetate: Slightly soluble
SMILES
ClC1=C(Cl)C(Cl)=C2C3=C(C(Cl)=C(C(Cl)=C3)Cl)OC2=C1
InChi Code
InChI=1S/C12H2Cl6O/c13-4-1-3-7-6(2-5(14)8(15)10(7)17)19-12(3)11(18)9(4)16/h1-2H
InChi Key
JEYJJJXOFWNEHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    2.5 mg

    $388

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    Product Description

    1,2,3,6,7,8-Hexachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF).1 It induces expression of the genes encoding aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50s = 1.47 and 1.24 nM, respectively).2 It reduces weight, induces thymic atrophy, and induces the expression of genes encoding the cytochrome P450 (CYP) isoform CYP1A1 and 4-chlorobiphenyl hydroxylase in rats (ED50s = 3.2, 0.9, 0.35, and 0.21 µmol/kg, respectively).3 It has been found in the soil near municipal waste incinerators, in freshwater fish, and in human breastmilk.1,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harnly, M., Stephens, R., McLaughlin, C., et al. Polychlorinated dibenzo-p-dioxin and dibenzofuran contamination at metal recovery facilities, open burn sites, and a railroad car incineration facility. Environ. Sci. Technol. 29(3), 667-684 (1995).

    2. Bandiera, S., Sawyer, T., Romkes, M., et al. Polychlorinated dibenzofurans (PCDFs): Effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology 32(2), 131-144 (1984).

    3. Mason, G., Sawyer, T., Keys, B., et al. Polychlorinated dibenzofurans (PCDFs): Correlation between in vivo and in vitro structure-activity relationships. Toxicology 37(1-2), 1-12 (1985).

    4. Zacharewski, T., Safe, L., Safe, S., et al. Comparative analysis of polychlorinated dibenzo-p-dioxin and dibenzofuran congeners in Great Lakes fish extracts by gas chromatography-mass spectrometry and in-vitro enzyme induction activities. Environ. Sci. Technol. 23(6), 730-735 (1989).

    5. Takekuma, M., Saito, K., Ogawa, M., et al. Levels of PCDDs, PCDFs and Co-PCBs in human milk in Saitama, Japan, and epidemiological research. Chemosphere 54(1), 127-135 (2004).