A dATP derivative
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8-Bromo-2'-deoxyadenosine-5'-O-triphosphate (sodium salt)

Item No. 38661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-2′-deoxy-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
CAS Number
1188369-62-1
Synonyms
  • 8-bromo dATP
Molecular Formula
C10H11BrN5O12P3 • 4Na
Formula Weight
658.0
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@@H](COP(OP(OP([O-])([O-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2Br)C1.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H15BrN5O12P3.4Na/c11-10-15-7-8(12)13-3-14-9(7)16(10)6-1-4(17)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;;/h3-6,17H,1-2H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20);;;;/q;4*+1/p-4/t4-,5+,6+;;;;/m0..../s1
InChi Key
QREXPILMFOGGCW-ZRRPJPAHSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    2.9 mg

    $197

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    Product Description

    8-Bromo-2'-deoxyadenosine-5'-O-triphosphate is a derivative of the nucleoside triphosphate dATP (Item No. 32566).1,2 It has been used to determine the substrate specificity of DNA polymerases and mutT homolog 1 (MTH1).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cahová, H., Pohl, R., Bednárová, L., et al. Synthesis of 8-bromo-, 8-methyl- and 8-phenyl-dATP and their polymerase incorporation into DNA. Org. Biomol. Chem. 6(20), 3657-3660 (2008).

    2. Kamiya, H., Yakushiji, H., Dugué, L., et al. Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. J. Mol. Biol. 336(4), 843-850 (2004).