A P2Y14 receptor agonist
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Uridine 5'-methylenediphosphate (sodium salt)

Item No. 38691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-[hydrogen P-(phosphonomethyl)phosphonate], uridine, trisodium salt
Synonyms
  • α,β-methylene UDP
  • UMP-CP
Molecular Formula
C10H13N2O11P2 • 3Na
Formula Weight
468.1
Purity
≥95%
Formulation (Request formulation change)
A solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(N(C=C1)[C@H]2[C@H](O)[C@H](O)[C@@H](COP([O-])(CP([O-])([O-])=O)=O)O2)NC1=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H16N2O11P2.3Na/c13-6-1-2-12(10(16)11-6)9-8(15)7(14)5(23-9)3-22-25(20,21)4-24(17,18)19;;;/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,11,13,16)(H2,17,18,19);;;/q;3*+1/p-3/t5-,7-,8-,9-;;;/m1.../s1
InChi Key
PPNYLVLWHITMFG-WKMNQBAXSA-K
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    2 mg

    $280

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    Product Description

    Uridine 5’-methylenediphosphate (UMP-CP) is an agonist of the purinergic P2Y14 receptor and a hydrolytically stable derivative of UDP (Item No. 18137).1,2 It selectively inhibits cAMP production in cells expressing human P2Y14 over those expressing human P2Y6 (EC50s = 11 and 339 nM, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Das, A., Ko, H., Burianek, L., et al. Human P2Y14 receptor agonists: Truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. J. Med. Chem. 53(1), 471-480 (2010).

    2. Ko, H., Carter, R.L., Cosyn, L., et al. Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg. Med. Chem. 16(12), 6319-6332 (2008).