An agonist of P2Y6
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UDP (sodium salt hydrate)

Item No. 18137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
uridine 5'-(trihydrogen diphosphate), disodium salt, hydrate
Synonyms
  • Uridine-5'-diphosphate
Molecular Formula
C9H12N2O12P2 • 2Na [XH2O]
Formula Weight
448.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
OP(OP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=CC(NC2=O)=O)O1)([O-])=O)([O-])=O.[Na+].[Na+].O
InChi Code
InChI=1S/C9H14N2O12P2.2Na.H2O/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
InChi Key
RHBXRWOXLRCWIZ-LLWADOMFSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    UDP is the diphosphate of the nucleoside uridine. It is a specific agonist of the P2Y purinoceptor P2Y6 (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction.1,2,3,4,5,6 UDP also acts as an antagonist of P2Y14, whose agonists include UDP-glucose (Item No. 15602), UDP-galactose, and UDP-glucuronic acid.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).

    2. Abbracchio, M.P., Burnstock, G., Boeynaems, J.M., et al. International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 58(3), 281-341 (2006).

    3. Garcia, R.A., Yan, M., Search, D., et al. P2Y6 receptor potentiates pro-inflammatory responses in macrophages and exhibits differential roles in atherosclerotic lesion development. PLoS One 9(10), 1-13 (2014).

    4. Inoue, K. UDP facilitates microglial phagocytosis through P2Y6 receptors. Cell Adh. Migr. 1(3), 131-132 (2007).

    5. Besada, P., Shin, D.H., Costanzi, S., et al. Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor. J. Med. Chem. 49(18), 5532-5543 (2006).

    6. Mitchell, C., Syed, N., Tengah, A., et al. Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J. Pharmacol. Exp. Ther. 343(3), 755-762 (2012).